Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009001)
Formula
SVG example
2-hydroxylation
Reactant Clomipramine Product 2-hydroxyclomipramine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - 2-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009013 Clomipramine 10-OH-clomipramine Oxidation - Aliphatic hydroxylation Clomipramine [1]
MR009005 Clomipramine 8-hydroxyclomipramine Oxidation - 8-hydroxylation Clomipramine [1]
MR009012 Clomipramine 8-OH-clomipramine Oxidation - Aromatic hydroxylation Clomipramine [1]
MR009011 Clomipramine Clomipramine N-oxide Unclear - Unclear Clomipramine [2]
MR009009 Clomipramine Desmethylclomipramine Oxidation - N-demethylation Clomipramine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006571 Clomipramine hydrochloride 2-hydroxyclomipramine Oxidation - 2-hydroxylation Clomipramine hydrochloride [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006573 2-hydroxyclomipramine 2-hydroxyclomipramine glucuronide Conjugation - Glucuronidation Clomipramine hydrochloride [3]
MR009004 2-hydroxyclomipramine 2-hydroxyclomipramine glucuronide Conjugation - Glucuronidation Clomipramine [1]
MR006572 2-hydroxyclomipramine 2-hydroxydesmethyl clomipramine Oxidation - Demethylation Clomipramine hydrochloride [3]
MR009002 2-hydroxyclomipramine 2-hydroxydesmethyl clomipramine Oxidation - Demethylation Clomipramine [1]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 DrugBank(Pharmacology-Metabolism):Clomipramine
3 Determination of clomipramine or imipramine and their mono-demethylated metabolites in human blood or plasma by high-performance liquid chromatography

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.