Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006601)
Formula
CYP3A4 ...
SVG example
Oxidationn
Reactant Desmethyl-dabrafenib Product M31-Dabrafenib
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006599 Carboxy-dabrafenib Desmethyl-dabrafenib Oxidation - Decarboxylation Dabrafenib mesylate [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006600 Desmethyl-dabrafenib M30-Dabrafenib Oxidation - Oxidationn Dabrafenib mesylate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006602 M31-Dabrafenib Dabrafenib mesylate Metabolite M26 Unclear Dabrafenib mesylate [1]
References
1 Metabolism and disposition of oral dabrafenib in cancer patients: proposed participation of aryl nitrogen in carbon-carbon bond cleavage via decarboxylation following enzymatic oxidation

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