Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006629)
Formula
SVG example
Reactant Dopamine hydrochloride Product 3-MT
Reactant Info Product Info
Metabolic Enzyme Catechol O-methyltransferase (COMT) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006632 Dopamine hydrochloride 6-Hydroxydopamine Unclear Dopamine hydrochloride [1]
MR006626 Dopamine hydrochloride DHPA Unclear Dopamine hydrochloride [2]
MR006634 Dopamine hydrochloride Dopamine 3-O-sulfate Unclear Dopamine hydrochloride [1]
MR006633 Dopamine hydrochloride Dopamine 4-sulfate Unclear Dopamine hydrochloride [1]
MR006635 Dopamine hydrochloride Dopamine glucuronide Unclear Dopamine hydrochloride [1]
MR006636 Dopamine hydrochloride Dopamine quinone Unclear Dopamine hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001485 Dopamine 3-Methoxytyramine Conjugation - O-Methylation Levodopa [3]
MR008913 Dopamine 3-methoxytyramine Unclear - Unclear Docarpamine [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006630 3-MT MHPA Unclear Dopamine hydrochloride [2]
MR001492 3-Methoxytyramine 3-methoxy-4-hydroxyacetaldehyde Oxidation - Oxidative Deamination Levodopa [3]
MR008914 3-methoxytyramine Homovanillic acid Unclear - Unclear Docarpamine [4]
References
1 DrugBank(Pharmacology-Metabolism): Dopamine hydrochloride
2 Membrane bound catechol-O-methytransferase is the dominant isoform for dopamine metabolism in PC12 cells and rat brain
3 DrugBank(Pharmacology-Metabolism)Levodopa
4 Metabolism of a new orally active dopamine prodrug, N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine (TA-870) and dopamine after oral administration to rats and dogs

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