Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000093)
Formula
POR ...
SVG example
Reactant Adriamycin Product Doxorubicinol deoxaglycone
Reactant Info Product Info
Metabolic Enzyme NADPH-cytochrome P450 reductase (CPR) DME Info
Xanthine dehydrogenase/oxidase (XDH) DME Info
Quinone reductase 1 (NQO1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000096 Adriamycin Doxorubicin aglycone Unclear Adriamycin [1]
MR000094 Adriamycin Doxorubicin-semiquinone Unclear Adriamycin [1]
MR000095 Adriamycin Doxorubicinol Unclear Adriamycin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006677 Doxorubicin Doxorubicinol deoxaglycone Unclear Doxorubicin [2]
MR009957 7-deoxydoxorubicinane 7-deoxydaxorubicinol Unclear - Unclear Epirubicin [3]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 PharmGKB:Doxorubicin
3 Comparative effects of paclitaxel and docetaxel on the metabolism and pharmacokinetics of epirubicin in breast cancer patients

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