Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006696)
Formula
CYP3A4 ...
SVG example
Aliphatic hydroxylation
Reactant Dronabinol Product 11-OH-delata-Tetrahydrocannabinol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Aliphatic hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006686 Dronabinol 11-Hydroxy-delta-9-THC Oxidation - 11-hydroxylation Dronabinol [1], [2], [3], [4]
MR013922 Dronabinol 7-alpha-Hydroxy-delta-9-THC Oxidation - 7-hydroxylation Dronabinol [1]
MR006693 Dronabinol 7-beta-Hydroxy-delta-9-THC Oxidation - 7-hydroxylation Dronabinol [1]
MR006697 Dronabinol 7-OH-delta-9-Tetrahydrocannabinol Oxidation - Aliphatic hydroxylation Dronabinol [1], [5]
MR006698 Dronabinol 7alpha-OH-delta-9-Tetrahydrocannabinol Oxidation - Aliphatic hydroxylation Dronabinol [1], [5]
MR006694 Dronabinol 8-beta-Hydroxy-delta-9-THC Oxidation - 8-hydroxylation Dronabinol [1]
MR006691 Dronabinol 8-Hydroxy-delta-9-THC Oxidation - 8-hydroxylation Dronabinol [1]
MR006699 Dronabinol 8-OH-delta-9-Tetrahydrocannabinol Unclear Dronabinol [1], [5]
MR006700 Dronabinol 8alpha-OH-delta-9-Tetrahydrocannabinol Unclear Dronabinol [1], [5]
MR006695 Dronabinol 9-alpha,10-alpha-epoxyhexahydrocannabinol Oxidation - 9, 10-epoxidation Dronabinol [1], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003641 THC 11-OH-THC Oxidation - Hydrolyzationn GW-1000 [6]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003642 11-OH-THC THC-COOH Oxidation - Oxidationn GW-1000 [6]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 CYP2C-catalyzed delta9-tetrahydrocannabinol metabolism: kinetics, pharmacogenetics and interaction with phenytoin. Biochem Pharmacol. 2005 Oct 1;70(7):1096-103.
3 Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids
4 Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions
5 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
6 Techniques and technologies for the bioanalysis of Sativex?, metabolites and related compounds

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