Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)
General Information of Drug (ID: DR0548) | ||||||
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Drug Name |
Dronabinol
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Synonyms |
Deltanyne; Dronabinol; Dronabinolum; Dronabinolum [Latin]; Marinol; Namisol; TETRAHYDROCANNABINOL; delta(1)-Tetrahydrocannabinol; delta(9)-THC; delta(9)-Tetrahydrocannabinol; delta(9)-Tetrahydrocannibinol; delta(sup 1)-Thc; delta(sup 9)-Thc; delta-9-THC; delta-9-tetrahydrocannabinol; delta1-THC; delta1-Tetrahydrocannabinol; delta9-THC; delta9-Tetrahydrocannabinol; (-)-delta9-trans-Tetrahydrocannabinol; 1-trans-delta-9-Tetrahydrocannabinol; 1-trans-delta9-Tetrahydrocannabinol; 9-tetrahydrocannabinol; Abbott 40566; THC
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Indication | Anorexia nervosa [ICD11: 6B80] | Approved | [1] | |||
Structure | ||||||
3D MOL | 2D MOL | |||||
Pharmaceutical Properties | Molecular Weight | 314.5 | Topological Polar Surface Area | 29.5 | ||
Heavy Atom Count | 23 | Rotatable Bond Count | 4 | |||
Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 2 | |||
Cross-matching ID |
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The Metabolic Roadmap of This Drug | |||||
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The Full List of Drug Metabolites (DM) of This Drug | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References | ||||||
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1 | Dronabinol was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration. | |||||
2 | Increasing the intracellular availability of all-trans retinoic acid in neuroblastoma cells. Br J Cancer. 2005 Feb 28;92(4):696-704. | |||||
3 | Health control over the feeding of troops on the Western and 3d Belorussian Fronts during the Great Patriotic War years. Voen Med Zh. 1975 Jun;(6):86-8. | |||||
4 | CYP2C-catalyzed delta9-tetrahydrocannabinol metabolism: kinetics, pharmacogenetics and interaction with phenytoin. Biochem Pharmacol. 2005 Oct 1;70(7):1096-103. | |||||
5 | Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. | |||||
6 | Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes. Xenobiotica. 1996 Mar;26(3):275-84. | |||||
7 | Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions | |||||
8 | Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids | |||||
9 | Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742. |
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