Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006727)
Formula
MDD
SVG example
Reactant Flucytosine Product 5-FU
Reactant Info Product Info
Metabolic Enzyme mevalonate diphosphate decarboxylase (MDD) DME Info
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009800 5-FP 5-Fluoruracil (5-FU) Unclear - Unclear 5-FP [1]
MR010706 Emtricitabine Emtricitabine Metabolite M7 Unclear - Unclear Emtricitabine [2]
MR001058 Floxuridine 5-fluorouracil Unclear Floxuridine [3], [4]
MR009468 1-ethoxymethyl-5-fluorouracil 5-FU Unclear - Unclear EMITEFUR [5]
MR005270 5'-hydroxytegafur Fluorouracil Other reaction - Degradation Tegafur [6], [7]
MR005272 5-hydroxytegafur Fluorouracil Multi-steps Reaction - Hydrolysis; oxidation Tegafur-uracil [8]
MR002522 5'-DFUR 5-fluorouracil Hydrolysis - Hydrolysis Capecitabine [9], [10]
MR010337 5'-DFUR 5-FU Unclear - Unclear Galocitabine [11]
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Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006754 5-FU FdUMP Unclear Fluorouracilo [12]
MR006748 5-FU FUrd Unclear Fluorouracilo [12]
MR001055 5-fluorouracil 5,6-Dihydro-5-fluorouracil Reduction - Reduction Floxuridine [3], [4]
MR006734 5-FU FdUMP Unclear Flucytosine [12]
MR006728 5-FU FUrd Unclear Flucytosine [12]
MR005277 Fluorouracil 5-fluorodeoxyuridine-monophosphate Conjugation - Phosphorylation Tegafur-uracil [8]
MR005278 Fluorouracil 5-fluorouridine-triphosphate Conjugation - Phosphorylation Tegafur-uracil [8]
MR005273 Fluorouracil 5-FUH2 Oxidation - Dehydrogenation Tegafur-uracil [8]
MR002524 5-fluorouracil FUH2 Reduction - Reduction Capecitabine [10]
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References
1 Phase I clinical trial of 5-fluoro-pyrimidinone (5FP), an oral prodrug of 5-fluorouracil (5FU)
2 Hplc-nmr identification of the human urinary metabolites of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analogue active against human immunodeficiency virus (HIV)
3 Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability. Mol Pharm. 2008 Sep-Oct;5(5):717-27.
4 The achievement of mass balance by simultaneous quantification of floxuridine prodrug, floxuridine, 5-fluorouracil, 5-dihydrouracil, -fluoro--ureidopropionate, -fluoro--alanine using LC-MS J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Apr 15;879(13-14):915-20. doi: 10.1016/j.jchromb.2011.02.045.
5 Phase I assessment of the pharmacokinetics, metabolism, and safety of emitefur in patients with refractory solid tumors
6 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
7 Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
8 DrugBank(Pharmacology-Metabolism):Tegafur-uracil
9 EUCRISA? (crisaborole) ointment, 2%, for topical use
10 A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma
11 Measurement of ascorbic acid in human aqueous humour and plasma and bovine aqueous humour by high-performance liquid chromatography with electrochemical detection
12 Study of the metabolism of flucytosine in Aspergillus species by 19F nuclear magnetic resonance spectroscopy

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