Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006831)
Formula
SVG example
Oxidationn; hydrolysis
Reactant Sonidegib phosphate Product Sonidegib metabolite M48
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Multi-steps Reaction - Oxidationn; hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006832 Sonidegib phosphate Sonidegib metabolite M16 Multi-steps Reaction - Oxidationn; hydrolysis Sonidegib phosphate [1]
MR006830 Sonidegib phosphate Sonidegib metabolite M25 Multi-steps Reaction - Oxidationn; hydrolysis Sonidegib phosphate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011780 LDE225 LDE225 Metabolite M48 Unclear - Unclear LDE225 [2]
References
1 Sonidegib: first global approval. Drugs. 2015 Sep;75(13):1559-66.
2 Absorption, distribution, metabolism, and excretion (ADME) of 1?C-sonidegib (LDE225) in healthy volunteers

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