Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006846)
Formula
CYP2C8 ...
SVG example
Hydrolyzationn; sulfadiazine acetylation
Reactant Sulfadiazine Product Sulfadiazine hydroxylamine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
N-acetyltransferase 2 (NAT2) DME Info
Methylenetetrahydrofolate reductase (MTHFR) DME Info
Metabolic Type Multi-steps Reaction - Hydrolyzationn; sulfadiazine acetylation
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006847 Sulfadiazine hydroxylamine 4-Hydroxysulfadiazine Unclear Sulfadiazine [1]
References
1 Identification of cytochrome P450 and arylamine N-acetyltransferase isoforms involved in sulfadiazine metabolism. Drug Metab Dispos. 2005 Jul;33(7):969-76.

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