Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006849)
Formula
CYP2D6 ...
SVG example
N-demethylation
Reactant Eletriptan hydrobromide Product N-Desmethyl eletriptan
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006850 Eletriptan hydrobromide Eletriptan N-Oxide Oxidation - N-oxidation Eletriptan hydrobromide [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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