Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006887)
Formula
SVG example
Oxidationn
Reactant 4-(2-Aminopropyl)phenol Product (-)-4-Hydroxynorephedrin
Reactant Info Product Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000220 Amphetamine 4-hydroxyamphetamine Oxidation - Hydroxylation Amphetamine [1]
MR000810 Dextroamphetamine 4-hydroxyamphetamine Oxidation - Hydroxylation Dextroamphetamine [2]
MR005819 Methoxyamphetamine beta 4-hydroxyamphetamine Oxidation - #NAME? Methoxyamphetamine beta [3], [4]
MR009989 Amphetamine 4-Hydroxyamphetamine Unclear - Unclear Metamfetamine [5]
MR010005 Amphetamine 4-Hydroxyamphetamine Unclear - Unclear Methamphetamine hydrochloride [5]
MR006886 D-amphetamine 4-(2-Aminopropyl)phenol Oxidation - Oxidationn Lisdexamfetamine [6]
MR006299 Fenethylline Metabolite M-1(AP ) Fenethylline Metabolite M-5( p-hydroxy-AP) Unclear Fenethylline [7]
MR009992 P-hydroxymethamphetamine 4-Hydroxyamphetamine Unclear - Unclear Metamfetamine [5]
MR010008 P-hydroxymethamphetamine 4-Hydroxyamphetamine Unclear - Unclear Methamphetamine hydrochloride [5]
MR007171 Amphetamine p-Hydroxyamphetamine Oxidation - p-hydroxylation Famprofazone [8]
MR007174 p-Hydroxymethamphetamine p-Hydroxyamphetamine Oxidation - N-demethylation Famprofazone [8]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000809 4-hydroxyamphetamine 4-hydroxyamphetamine glucuronide Conjugation - Glucuronidation Dextroamphetamine [2]
MR000217 4-hydroxyamphetamine 4-hydroxynorephedrine Oxidation - Hydroxylation Amphetamine [9]
MR000808 4-hydroxyamphetamine Sulfated 4-hydroxyamphetamine Conjugation - Sulfation Dextroamphetamine [2]
MR009990 4-Hydroxyamphetamine 4-Hydroxynorephedrine Unclear - Unclear Metamfetamine [5]
MR010006 4-Hydroxyamphetamine 4-Hydroxynorephedrine Unclear - Unclear Methamphetamine hydrochloride [5]
⏷ Show the Full List of MR
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006889 Norephedrine (-)-4-Hydroxynorephedrin Oxidation - Oxidationn Lisdexamfetamine [6]
References
1 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
2 Clinical pharmacokinetics of amfetamine and related substances: monitoring in conventional and non-conventional matrices Clin Pharmacokinet. 2004;43(3):157-85. doi: 10.2165/00003088-200443030-00002.
3 Interactions of amphetamine analogs with human liver CYP2D6. Biochem Pharmacol. 1997 Jun 1;53(11):1605-12.
4 Interindividual and interspecies variation in the metabolism of the hallucinogen 4-methoxyamphetamine
5 Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat
6 Preclinical pharmacokinetics, pharmacology and toxicology of lisdexamfetamine: a novel d-amphetamine pro-drug. Neuropharmacology. 2014 Dec;87:41-50.
7 Metabolic fate of fenetylline in rat and man
8 Identification of new urinary metabolites of famprofazone in humans
9 DrugBank(Pharmacology-Metabolism)Amphetamine

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.