Details of the Metabolic Reaction (MR)
General Information of This Metabolic Reaction (MR) (ID: MR000810) | ||||||
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Formula |
Hydroxylation
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Reactant | Dextroamphetamine | Product | 4-hydroxyamphetamine | |||
Reactant Info | Product Info | |||||
Metabolic Enzyme | Cytochrome P450 2D6 (CYP2D6) | DME Info | ||||
Metabolic Type | Oxidation - Hydroxylation | |||||
References | ||||||
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1 | Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742. | |||||
2 | Interactions of amphetamine analogs with human liver CYP2D6. Biochem Pharmacol. 1997 Jun 1;53(11):1605-12. | |||||
3 | Interindividual and interspecies variation in the metabolism of the hallucinogen 4-methoxyamphetamine | |||||
4 | Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat | |||||
5 | Preclinical pharmacokinetics, pharmacology and toxicology of lisdexamfetamine: a novel d-amphetamine pro-drug. Neuropharmacology. 2014 Dec;87:41-50. | |||||
6 | Metabolic fate of fenetylline in rat and man | |||||
7 | Identification of new urinary metabolites of famprofazone in humans | |||||
8 | Clinical pharmacokinetics of amfetamine and related substances: monitoring in conventional and non-conventional matrices Clin Pharmacokinet. 2004;43(3):157-85. doi: 10.2165/00003088-200443030-00002. | |||||
9 | DrugBank(Pharmacology-Metabolism)Amphetamine |
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