Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007102)
Formula
CYP2D6 ...
SVG example
N-dealkylation
Reactant Dexfenfluramine Product Nordexfenfluramine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007103 Nordexfenfluramine 1-(3-CF3 -phenyl)-propan-2-one Unclear Dexfenfluramine [1]
MR007108 Nordexfenfluramine N-hydroxynordexfenfluramine Unclear Dexfenfluramine [1]
References
1 Metabolism of dexfenfluramine in human liver microsomes and by recombinant enzymes: role of CYP2D6 and 1A2. Pharmacogenetics. 1998 Oct;8(5):423-32.

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