Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007109)
Formula
CYP2D6 ...
SVG example
N-demethyiation
Reactant Dextropropoxyphene Product Nordextropropoxyphene
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-demethyiation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007111 Dextropropoxyphene Unclear Oxidation - Aromatic hydroxylation Dextropropoxyphene [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007110 Nordextropropoxyphene Dinordextropropoxyphene Oxidation - N-demethyiation Dextropropoxyphene [1]
References
1 CYP3A4 mediates dextropropoxyphene N-demethylation to nordextropropoxyphene: human in vitro and in vivo studies and lack of CYP2D6 involvement. Xenobiotica. 2004 Oct;34(10):875-87.

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