Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007220)
Formula
CYP3A4 ...
SVG example
Aliphatic hydroxylation
Reactant Glibenclamide Product 3-trans-Hydroxycyclohexyl glyburide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Aliphatic hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007218 Glibenclamide 2-trans-hydroxycyclohexyl glyburide Oxidation - Aliphatic hydroxylation Glibenclamide [1], [2]
MR007222 Glibenclamide 3-cis-Hydroxycyclohexyl glyburide Oxidation - Aliphatic hydroxylation Glibenclamide [1], [2], [3]
MR007219 Glibenclamide 4-cis-hydroxycyclohexyl glyburide Oxidation - Aliphatic hydroxylation Glibenclamide [1], [2]
MR007221 Glibenclamide Ethylhydroxycyclohexyl glyburide Oxidation - Aliphatic hydroxylation Glibenclamide [1], [2]
References
1 Kinetics of glyburide metabolism by hepatic and placental microsomes of human and baboon
2 Identification of CYP3A7 for glyburide metabolism in human fetal livers. Biochem Pharmacol. 2014 Dec 15;92(4):690-700.
3 Identification of glyburide metabolites formed by hepatic and placental microsomes of humans and baboons

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