Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM006693)
DM Name	Ethylhydroxycyclohexyl glyburide

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2C9 (CYP2C9)	DME0019	Glibenclamide	Oxidation - Aliphatic hydroxylation	Glibenclamide	[1] , [2]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Glibenclamide	Oxidation - Aliphatic hydroxylation	Glibenclamide	[1] , [2]
Cytochrome P450 3A5 (CYP3A5)	DME0012	Glibenclamide	Oxidation - Aliphatic hydroxylation	Glibenclamide	[1] , [2]
Cytochrome P450 3A7 (CYP3A7)	DME0015	Glibenclamide	Oxidation - Aliphatic hydroxylation	Glibenclamide	[1] , [2]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	Glibenclamide	Oxidation - Aliphatic hydroxylation	Glibenclamide	[1] , [2]

Full List of Drug(s) That Produce This DM By Metabolism
Glibenclamide		DR0775	Phase 4		Diabetes mellitus

References
1	Kinetics of glyburide metabolism by hepatic and placental microsomes of human and baboon
2	Identification of CYP3A7 for glyburide metabolism in human fetal livers. Biochem Pharmacol. 2014 Dec 15;92(4):690-700.

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