| General Information of Drug Metabolite (DM) (ID: DM006725) |
| DM Name |
Catechol intermediate
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Quinone reductase 1 (NQO1)
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DME0097
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| Reduction - Reduction |
ARQ-501
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[1] |
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| DME(s) Metabolizing This DM |
| DME Name |
DME ID |
Product |
Reaction |
Related Drug |
REF |
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UDP-glucuronosyltransferase 1A7 (UGT1A7)
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DME0065
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| Conjugation - Monoglucuronidation |
ARQ-501
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[1] |
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UDP-glucuronosyltransferase 1A8 (UGT1A8)
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DME0064
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| Conjugation - Monoglucuronidation |
ARQ-501
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[1] |
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UDP-glucuronosyltransferase 1A9 (UGT1A9)
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DME0042
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| Conjugation - Monoglucuronidation |
ARQ-501
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[1] |
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UDP-glucuronosyltransferase 2B7 (UGT2B7)
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DME0040
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| Conjugation - Monoglucuronidation |
ARQ-501
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| ARQ-501 |
DR1869
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Phase 2 |
Leiomyosarcoma |
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| References |
| 1 |
Metabolic profile, enzyme kinetics, and reaction phenotyping of -lapachone metabolism in human liver and intestine in vitro
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