Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007274)
Formula
CYP1A2 ...
SVG example
Reactant ASA-404 Product 6-OH-MXAA
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Flavin-containing monooxygenase (FMO) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007276 ASA-404 DMXAA acyl glucuronide Unclear ASA-404 [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007275 6-OH-MXAA 6-OH-MXAA glucuronide Unclear ASA-404 [1], [2]
References
1 Predicting pharmacokinetics and drug interactions in patients from in vitro and in vivo models: the experience with 5,6-dimethylxanthenone-4-acetic acid (DMXAA), an anti-cancer drug eliminated mainly by conjugation. Drug Metab Rev. 2002 Nov;34(4):751-90.
2 Preclinical factors affecting the interindividual variability in the clearance of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid. Biochem Pharmacol. 2003 Jun 1;65(11):1853-65.

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