Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007449)
Formula
SVG example
Oxidationn
Reactant Ethanol Product Acetaldehyde
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2E1 (CYP2E1) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007452 Ethanol EtG Unclear Ethanol [1]
MR007453 Ethanol Unclear Unclear Ethanol [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000453 BRN-1736748 Acetaldehyde Unclear BRN-1736748 [3], [4]
MR008004 Cefuroxime axetil Acetaldehyde Unclear - Unclear Cefuroxime axetil [5]
MR004377 Nitrophenyl acetate Acetaldehyde Unclear Nitrophenyl acetate [6]
MR005911 2-deoxy-D-ribose 5-phosphate (DR5P) Acetaldehyde Unclear Thymidine [7]
MR004209 PYR Acetaldehyde Unclear D-xylulose [8]
MR004160 4-Hydroxy-2-oxovaleric acid Acetaldehyde Unclear Aminophenol [9]
⏷ Show the Full List of MR
References
1 Identification and preliminary characterization of UDP-glucuronosyltransferases catalyzing formation of ethyl glucuronide. Anal Bioanal Chem. 2014 Apr;406(9-10):2325-32.
2 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
3 Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease Nature. 2011 Apr 7;472(7341):57-63. doi: 10.1038/nature09922.
4 NORMAN Suspect List Exchange:Choline
5 DrugBank(Pharmacology-Metabolism):Cefuroxime axetil
6 Aldehyde dehydrogenase catalyses acetaldehyde formation from 4-nitrophenyl acetate and NADH
7 Thymidine catabolism as a metabolic strategy for cancer survival. Cell Rep. 2017 May 16;19(7):1313-1321.
8 Effects of increased transaldolase activity on D-xylulose and D-glucose metabolism in Saccharomyces cerevisiae cell extracts
9 Metabolism of 2-aminophenol by Pseudomonas sp. AP-3: modified meta-cleavage pathway

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