Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007655)
Formula
AOC1 ...
SVG example
Reactant Putrescine Product -aminobutyric acid
Reactant Info Product Info
Metabolic Enzyme Amiloride-sensitive amine oxidase (AOC1) DME Info
aldehyde dehydrogenase (ALDH) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007654 Putrescine Spermidine Other reaction - N-Decarboxylation Putrescine [1]
MR007653 Putrescine Spermine Other reaction - Decarboxylation Putrescine [1]
MR003077 Putrescine MTA Unclear Agmatine [2]
MR003067 Putrescine Spermidine Unclear Agmatine [2], [3], [4]
MR012735 Putrescine Spermidine Unclear - Unclear Arginine [5]
MR012737 Putrescine Y-amino-butyraldehyde Unclear - Unclear Arginine [5]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012760 Gamma hydroxybutyric acid GABA Unclear - Unclear Gamma hydroxybutyric acid [6]
MR012753 L-glutamic acid GABA Unclear - Unclear L-glutamic acid [7]
MR001523 L-glutamate GABA Oxidation - Decarboxylation L-glutamine [8], [9]
MR003074 Gamma-guanidinobutyrate Gamma-aminobutyrate Unclear Agmatine [2]
MR012743 L-Glutamate GABA Unclear - Unclear Arginine [5]
MR012738 Y-amino-butyraldehyde GABA Unclear - Unclear Arginine [5]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012761 GABA Glutamate Unclear - Unclear Gamma hydroxybutyric acid [6]
References
1 Human aldehyde dehydrogenase: metabolism of putrescine and histamine
2 Metabolism and function in animal tissues of agmatine, a biogenic amine formed from arginine Amino Acids. 2004 Feb;26(1):3-8. doi: 10.1007/s00726-003-0030-z.
3 Genome-wide analysis of polyamine biosynthesis genes in wheat reveals gene expression specificity and involvement of STRE and MYB-elements in regulating polyamines under drought. BMC Genomics. 2022 Oct 30;23(1):734. doi: 10.1186/s12864-022-08946-2.
4 Unique Chemistry, Intake, and Metabolism of Polyamines in the Central Nervous System (CNS) and Its Body. Biomolecules. 2022 Mar 25;12(4):501. doi: 10.3390/biom12040501.
5 Arginine Metabolism Revisited
6 U. S. FDA Label -Gamma hydroxybutyric acid
7 Determination and Application of Nineteen Monoamines in the Gut Microbiota Targeting Phenylalanine, Tryptophan, and Glutamic Acid Metabolic Pathways
8 Glutamate decarboxylase-dependent acid resistance in orally acquired bacteria: function, distribution and biomedical implications of the gadBC operon. Mol Microbiol. 2012 Nov;86(4):770-86.
9 The delta subunit of the GABA(A) receptor is necessary for the GPT2-promoted breast cancer metastasis. Theranostics. 2023 Feb 21;13(4):1355-1369. doi: 10.7150/thno.80544.

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