Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008030)
Formula
SVG example
N-demethylation
Reactant Levomethadyl Acetate Product Noracymethadol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008028 Levomethadyl Acetate Nor-levomethadyl acetate (nor-LAAM) Oxidation - N-demethylation Levomethadyl Acetate [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003113 Levomethadyl acetate hydrochloride NorLAAM Oxidation - Demethylation Levomethadyl acetate hydrochloride [3], [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003112 NorLAAM Dinor-levomethadyl acetate Oxidation - Demethylation Levomethadyl acetate hydrochloride [4]
References
1 The KEGG resource for deciphering the genome
2 Differential N-demethylation of l-alpha-acetylmethadol (LAAM) and norLAAM by cytochrome P450s 2B6, 2C18, and 3A4
3 Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies. Clin Pharmacokinet. 2005;44(7):731-51.
4 N-demethylation of levo-alpha-acetylmethadol by human placental aromatase. Biochem Pharmacol. 2004 Mar 1;67(5):885-92.

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