Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008106)
Formula
SVG example
Hydrolysis
Reactant Penicillin G Sodium Product 6-aminopenicillanic acid
Reactant Info Product Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008103 Penicillin G Sodium Penicillin G Sodium metabolite M3 Unclear - Unclear Penicillin G Sodium [1]
MR008105 Penicillin G Sodium Penicillin G Sodium metabolite M7 Unclear - Unclear Penicillin G Sodium [1]
MR008099 Penicillin G Sodium Penicilloic acid Oxidation - Oxidation Penicillin G Sodium [1]
MR008108 Penicillin G Sodium Phenyl acetic acid Hydrolysis - Hydrolysis Penicillin G Sodium [2]
MR008107 Penicillin G Sodium Phenylacetyl-7-aminodeacetoxycephalosporanic acid (G-7-ADCA) Unclear - Unclear Penicillin G Sodium [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008098 Cyclacillin 6-APA Hydrolysis - Hydrolysis Cyclacillin [4]
MR008130 Penicillin 6-aminopenicillanic acid Unclear - Unclear Penicillin [5], [6]
MR001971 Penicillin G 6-aminopenicillanic acid Unclear Penicillin G [7]
MR008112 Penicillin V 6-aminopenicillanic acid Unclear - Unclear Penicillin V [8]
References
1 Identification of new minor metabolites of penicillin G in human serum by multiple-stage tandem mass spectrometry
2 A breakthrough in enzyme technology to fight penicillin resistance-industrial application of penicillin amidase
3 Whole-Cell Biotransformation of Penicillin G by a Three-Enzyme Co-expression System with Engineered Deacetoxycephalosporin?C Synthase
4 Sex- and species-related nephropathy of 6-(1-aminocyclohexanecarboxamido)penicillanic acid (cyclacillin) and its relationship to the metabolic disposition of the drug
5 Metabolism of penicillins to penicilloic acids and 6-aminopenicillanic acid in man and its significance in assessing penicillin absorption
6 Ligand-induced conformational change in penicillin acylase
7 McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 1999. Bethesda, MD:American Society of Health-System Pharmacists, Inc. 1999 (Plus Supplements)., p. 1760
8 Specificity of penicillin acylase of Fusarium and of Penicillium chrysogenum

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