Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008303)
Formula
UGT1A1 ...
SVG example
Glucuronidation
Reactant LJN452 Product LJN452 metabolite M22
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 1A7 (UGT1A7) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008300 LJN452 LJN452 metabolite M11.6 Multi-steps Reaction - Oxidative; O-dealkylation LJN452 [1]
MR008294 LJN452 LJN452 metabolite M22.4 Oxidation - Oxidation LJN452 [1]
MR008296 LJN452 LJN452 metabolite M24 Unclear - Unclear LJN452 [1]
References
1 Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1-mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependence of Tropifexor Metabolism

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.