Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008296)
Formula Reactant LJN452 Product LJN452 metabolite M24
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008300 LJN452 LJN452 metabolite M11.6 Multi-steps Reaction - Oxidative; O-dealkylation LJN452 [1]
MR008303 LJN452 LJN452 metabolite M22 Conjugation - Glucuronidation LJN452 [1]
MR008294 LJN452 LJN452 metabolite M22.4 Oxidation - Oxidation LJN452 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008299 LJN452 metabolite M24 LJN452 metabolite M18.1 Other reaction - Hydration LJN452 [1]
MR008297 LJN452 metabolite M24 LJN452 metabolite M18.2 Oxidation - Oxidation LJN452 [1]
MR008298 LJN452 metabolite M24 LJN452 metabolite M19.5 Oxidation - Oxidation LJN452 [1]
References
1 Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1-mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependence of Tropifexor Metabolism

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.