Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008294)
Formula Reactant LJN452 Product LJN452 metabolite M22.4
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008300 LJN452 LJN452 metabolite M11.6 Multi-steps Reaction - Oxidative; O-dealkylation LJN452 [1]
MR008303 LJN452 LJN452 metabolite M22 Conjugation - Glucuronidation LJN452 [1]
MR008296 LJN452 LJN452 metabolite M24 Unclear - Unclear LJN452 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008295 LJN452 metabolite M22.4 LJN452 metabolite M18.2 Oxidation - Oxidation LJN452 [1]
References
1 Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1-mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependence of Tropifexor Metabolism

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