Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008300)
Formula
SVG example
Oxidative; O-dealkylation
Reactant LJN452 Product LJN452 metabolite M11.6
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Multi-steps Reaction - Oxidative; O-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008303 LJN452 LJN452 metabolite M22 Conjugation - Glucuronidation LJN452 [1]
MR008294 LJN452 LJN452 metabolite M22.4 Oxidation - Oxidation LJN452 [1]
MR008296 LJN452 LJN452 metabolite M24 Unclear - Unclear LJN452 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008301 LJN452 metabolite M11.6 LJN452 metabolite M6 Oxidation - Oxidation LJN452 [1]
MR008302 LJN452 metabolite M11.6 LJN452 metabolite M6.7 Conjugation - Glucuronidation LJN452 [1]
References
1 Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1-mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependence of Tropifexor Metabolism

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