Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008317)
Formula
UGT1A4 ...
SVG example
Glucuronidation
Reactant ABT-126 Product ABT-126 metabolite M11
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info
UDP-glucuronosyltransferase 2B10 (UGT2B10) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008312 ABT-126 ABT-126 metabolite M1 Oxidation - Oxidation ABT-126 [1]
MR008319 ABT-126 ABT-126 metabolite M10 Multi-steps Reaction - Oxidation; cysteine conjugation ABT-126 [1]
MR008316 ABT-126 ABT-126 metabolite M12 Conjugation - Glucose conjugation ABT-126 [1]
MR008318 ABT-126 ABT-126 metabolite M7 Multi-steps Reaction - Di-oxidation; sulfation ABT-126 [1]
MR008315 ABT-126 ABT-126 metabolite M8 Multi-steps Reaction - Oxidation; glucuronidation ABT-126 [1]
References
1 Metabolism and Disposition of a Novel Selective 7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in Catalysis

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