Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008697)
Formula
SVG example
Sulfation
Reactant Methyldopate Hydrochloride Product Alpha-methyldopa-mono-O-sulfate
Reactant Info Product Info
Metabolic Enzyme Sulfotransferase (SULT) DME Info
Metabolic Type Conjugation - Sulfation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008695 Methyldopate Hydrochloride 3,4-Dihydroxyphenylacetone Multi-steps Reaction - Deamination; decarboxylation Methyldopate Hydrochloride [1], [2], [3]
MR008693 Methyldopate Hydrochloride 3-O-methyl-alpha-methyldopa Conjugation - O-methylation Methyldopate Hydrochloride [4], [5], [1]
MR008689 Methyldopate Hydrochloride Alpha-methyldopamine Reduction - Decarboxylation Methyldopate Hydrochloride [6], [4], [5], [1]
References
1 THE METABOLISM OF METHYLDOPA IN HYPERTENSIVE HUMAN SUBJECTS
2 Clinical pharmacokinetics of methyldopa
3 Reaction of dopa decarboxylase with alpha-methyldopa leads to an oxidative deamination producing 3,4-dihydroxyphenylacetone, an active site directed affinity label
4 Sulfate and methyldopa metabolism: metabolite patterns and platelet phenol sulfotransferase activity. Clin Pharmacol Ther. 1985 Mar;37(3):308-15.
5 The metabolism of 14 C-labelled -methyldopa in normal and hypertensive human subjects
6 Antihypertensive metabolites of alpha-methyldopa

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