Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008695)
Formula
DDC
SVG example
Deamination; decarboxylation
Reactant Methyldopate Hydrochloride Product 3,4-Dihydroxyphenylacetone
Reactant Info Product Info
Metabolic Enzyme DOPA decarboxylase (DDC) DME Info
Metabolic Type Multi-steps Reaction - Deamination; decarboxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008693 Methyldopate Hydrochloride 3-O-methyl-alpha-methyldopa Conjugation - O-methylation Methyldopate Hydrochloride [1], [2], [3]
MR008697 Methyldopate Hydrochloride Alpha-methyldopa-mono-O-sulfate Conjugation - Sulfation Methyldopate Hydrochloride [3], [4], [1]
MR008689 Methyldopate Hydrochloride Alpha-methyldopamine Reduction - Decarboxylation Methyldopate Hydrochloride [5], [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008696 3,4-Dihydroxyphenylacetone 3,4-Dihydroxyphenylacetone glucuronide Conjugation - Glucuronidation Methyldopate Hydrochloride [6]
References
1 Sulfate and methyldopa metabolism: metabolite patterns and platelet phenol sulfotransferase activity. Clin Pharmacol Ther. 1985 Mar;37(3):308-15.
2 The metabolism of 14 C-labelled -methyldopa in normal and hypertensive human subjects
3 THE METABOLISM OF METHYLDOPA IN HYPERTENSIVE HUMAN SUBJECTS
4 Clinical pharmacokinetics of methyldopa
5 Antihypertensive metabolites of alpha-methyldopa
6 DrugBank(Pharmacology-Metabolism):Methyldopate Hydrochloride

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