Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008822)
Formula
CYP2D6 ...
SVG example
Hydroxylation
Reactant Tandospirone Product Tandospirone metabolite M4
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008816 Tandospirone 1\(2\pyrimidinyl)\piperazine (1\PP) Oxidation - Oxidative cleavage Tandospirone [1], [2]
MR008820 Tandospirone Tandospirone metabolite M2 Oxidation - Hydroxylation Tandospirone [2]
MR008818 Tandospirone Tandospirone metabolite Ma Unclear - Unclear Tandospirone [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008823 Tandospirone metabolite M4 Tandospirone metabolite M5 Unclear - Unclear Tandospirone [2]
References
1 Simultaneous determination of tandospirone and its active metabolite, 1-[2-pyrimidyl]-piperazine in rat plasma by LC-MS/MS and its application to a pharmacokinetic study
2 Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes

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