Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008816)
Formula
CYP2D6 ...
SVG example
Oxidative cleavage
Reactant Tandospirone Product 1\(2\pyrimidinyl)\piperazine (1\PP)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidative cleavage
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008820 Tandospirone Tandospirone metabolite M2 Oxidation - Hydroxylation Tandospirone [1]
MR008822 Tandospirone Tandospirone metabolite M4 Oxidation - Hydroxylation Tandospirone [1]
MR008818 Tandospirone Tandospirone metabolite Ma Unclear - Unclear Tandospirone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000523 Buspirone 1-Pyrimidinylpiperazine Oxidation - N-Dealkylation Buspirone [2], [3], [4]
MR012622 Gepirone 2-(1-Piperazinyl)pyrimidine Unclear - Unclear Gepirone [5]
MR001842 Org-33062 1-Pyrimidinylpiperazine Unclear Org-33062 [6]
MR013728 PF-00734200 PF-00734200 metabolite M3 Oxidation - N-dealkylation PF-00734200 [7]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012623 2-(1-Piperazinyl)pyrimidine 2-(Piperazin-1-yl)pyrimidin-5-ol Unclear - Unclear Gepirone [8]
MR008817 1\(2\pyrimidinyl)\piperazine (1\PP) 5-OH-1-PP Unclear - Unclear Tandospirone [1]
References
1 Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes
2 Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. Drug Metab Dispos. 2005 Apr;33(4):500-7.
3 DrugBank(Pharmacology-Metabolism)Buspirone
4 Interaction of buspirone and its major metabolites with human organic cation transporters. Fundam Clin Pharmacol. 2023 Feb 26. doi: 10.1111/fcp.12883.
5 Gepirone and 1-(2-pyrimidinyl)-piperazine in vitro: human cytochromes mediating transformation and cytochrome inhibitory effects
6 Human cytochromes mediating gepirone biotransformation at low substrate concentrations. Biopharm Drug Dispos. 2003 Mar;24(2):87-94.
7 Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human
8 PubChem:Gepirone

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