Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008832)
Formula
SVG example
Hydroxylation
Reactant Umeclidinium Product Umeclidinium M33
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008834 Umeclidinium Umeclidinium M14 Oxidation - O-dealkylation Umeclidinium [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013189 Umeclidinium bromide Umeclidinium M33 Oxidation - Hydroxylation Umeclidinium bromide [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008833 Umeclidinium M33 Umeclidinium M21 Conjugation - Glucuronidation Umeclidinium [3]
MR013191 Umeclidinium M33 Umeclidinium M21 Conjugation - Glucuronidation Umeclidinium bromide [2]
MR013190 Umeclidinium M33 Umeclidinium M34 Oxidation - Methylation Umeclidinium bromide [2]
References
1 Pharmacokinetics, metabolite profiling, safety, and tolerability of inhalation aerosol of 101BHG-D01, a novel, long-acting and selective muscarinic receptor antagonist, in healthy Chinese subjects
2 CLINICAL PHARMACOLOGY AND BIOPHARMACEUTICS REVIEW: Umeclidinium Bromide
3 DrugBank(Pharmacology-Metabolism):Umeclidinium

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