Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008988)
Formula
CYP2D6 ...
SVG example
Aliphatic hydroxylation
Reactant Almogran Product 2-OH-almotriptan
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Aliphatic hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008998 Almogran 1-[({3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}methane)sulfonyl]pyrrolidin-2-ol Oxidation - Oxidation Almogran [1]
MR008996 Almogran 2-{5-[(pyrrolidine-1-sulfonyl)methyl]-1H-indol-3-yl}acetic acid Oxidation - Oxidative deamination Almogran [1]
MR008997 Almogran 2-{5-[(pyrrolidine-1-sulfonyl)methyl]-1H-indol-3-yl}ethan-1-ol Oxidation - Oxidative deamination Almogran [1]
MR008999 Almogran Almogran metabolite A1 Oxidation - Oxidative deamination Almogran [2]
MR009000 Almogran Almogran metabolite M5 Oxidation - N-oxidation Almogran [2]
MR008991 Almogran Almogran metabolite P15 Oxidation - Oxidation Almogran [3]
MR008995 Almogran N-desmethylalmotriptan Oxidation - N-demethylation Almogran [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000153 Almotriptan malate Almotriptan malate metabolite M3 Oxidation - Pyrrolidine Oxidation Almotriptan malate [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000146 Almotriptan malate metabolite M3 ACP-5461 Other reaction - Tautomerisation Almotriptan malate [4]
MR008989 2-OH-almotriptan Almogran metabolite A2 Unclear - Unclear Almogran [2]
References
1 DrugBank(Pharmacology-Metabolism):Almogran
2 Almotriptan, a new anti-migraine agent: a review. CNS Drug Rev. 2002 Fall;8(3):217-34.
3 Disposition and metabolism of almotriptan in rats, dogs and monkeys Xenobiotica. 2006 Sep;36(9):807-23. doi: 10.1080/00498250600802508.
4 Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. Clin Pharmacokinet. 2005;44(3):237-46.

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