Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000153)
Formula
CYP3A4 ...
SVG example
Pyrrolidine Oxidation
Reactant Almotriptan malate Product Almotriptan malate metabolite M3
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Pyrrolidine Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000152 Almotriptan malate Almotriptan malate metabolite M1 Oxidation - Oxidative Deamination Almotriptan malate [1]
MR000156 Almotriptan malate Almotriptan malate metabolite M7 Oxidation - Deamination Almotriptan malate [2]
MR000155 Almotriptan malate LAS 31612 Oxidation - N-Demethylation Almotriptan malate [2], [1]
MR000154 Almotriptan malate LAS 32195 Oxidation - N-Oxidation Almotriptan malate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008988 Almogran 2-OH-almotriptan Oxidation - Aliphatic hydroxylation Almogran [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000146 Almotriptan malate metabolite M3 ACP-5461 Other reaction - Tautomerisation Almotriptan malate [1]
MR008989 2-OH-almotriptan Almogran metabolite A2 Unclear - Unclear Almogran [4]
References
1 Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. Clin Pharmacokinet. 2005;44(3):237-46.
2 Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metab Dispos. 2003 Apr;31(4):404-11.
3 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
4 Almotriptan, a new anti-migraine agent: a review. CNS Drug Rev. 2002 Fall;8(3):217-34.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.