Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009006)
Formula
CYP3A4 ...
SVG example
Unclear
Reactant 8-hydroxyclomipramine Product 8-hydroxydesmethyl clomipramine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009005 Clomipramine 8-hydroxyclomipramine Oxidation - 8-hydroxylation Clomipramine [1]
MR006574 Clomipramine hydrochloride 8-hydroxyclomipramine Oxidation - 8-hydroxylation Clomipramine hydrochloride [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006577 8-hydroxyclomipramine 8-hydroxyclomipramine glucuronide Conjugation - Glucuronidation Clomipramine hydrochloride [2]
MR009008 8-hydroxyclomipramine 8-hydroxyclomipramine glucuronide Conjugation - Glucuronidation Clomipramine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006576 8-hydroxydesmethyl clomipramine 8-hyroxydesmethyl clomipramine glucuronide Conjugation - Glucuronidation Clomipramine hydrochloride [2]
MR009007 8-hydroxydesmethyl clomipramine 8-hyroxydesmethyl clomipramine glucuronide Unclear - Unclear Clomipramine [1]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Metabolism of clomipramine in a Japanese psychiatric population: hydroxylation, desmethylation, and glucuronidation

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