Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006574)
Formula
SVG example
8-hydroxylation
Reactant Clomipramine hydrochloride Product 8-hydroxyclomipramine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - 8-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006580 Clomipramine hydrochloride 10-OH-clomipramine Oxidation - Aliphatic hydroxylation Clomipramine hydrochloride [1]
MR006571 Clomipramine hydrochloride 2-hydroxyclomipramine Oxidation - 2-hydroxylation Clomipramine hydrochloride [2]
MR006579 Clomipramine hydrochloride 8-OH-clomipramine Oxidation - Aromatic hydroxylation Clomipramine hydrochloride [2]
MR006578 Clomipramine hydrochloride Clomipramine N-oxide Oxidation - Oxidationn Clomipramine hydrochloride [1]
MR006567 Clomipramine hydrochloride Desmethylclomipramine Oxidation - N-demethylation Clomipramine hydrochloride [1], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009005 Clomipramine 8-hydroxyclomipramine Oxidation - 8-hydroxylation Clomipramine [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006577 8-hydroxyclomipramine 8-hydroxyclomipramine glucuronide Conjugation - Glucuronidation Clomipramine hydrochloride [1]
MR009008 8-hydroxyclomipramine 8-hydroxyclomipramine glucuronide Conjugation - Glucuronidation Clomipramine [4]
MR006575 8-hydroxyclomipramine 8-hydroxydesmethyl clomipramine Unclear Clomipramine hydrochloride [1]
MR009006 8-hydroxyclomipramine 8-hydroxydesmethyl clomipramine Unclear - Unclear Clomipramine [4], [5]
References
1 Metabolism of clomipramine in a Japanese psychiatric population: hydroxylation, desmethylation, and glucuronidation
2 Determination of clomipramine or imipramine and their mono-demethylated metabolites in human blood or plasma by high-performance liquid chromatography
3 Population pharmacokinetics of clomipramine, desmethylclomipramine, and hydroxylated metabolites in patients with depression receiving chronic treatment: model evaluation
4 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
5 The effect of CYP2C19 and CYP2D6 genotypes on the metabolism of clomipramine in Japanese psychiatric patients. J Clin Psychopharmacol. 2001 Dec;21(6):549-55.

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