Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009235)
Formula
CYP3A4 ...
SVG example
Oxidation
Reactant Ingrezza Product NBI-136110
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009236 Ingrezza (+)-alpha-HTBZ Hydrolysis - Hydrolysis Ingrezza [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002484 Valbenazine NBI-136110 Oxidation - Oxidation Valbenazine [1]
References
1 Pharmacologic Characterization of Valbenazine (NBI-98854) and Its Metabolites J Pharmacol Exp Ther. 2017 Jun;361(3):454-461. doi: 10.1124/jpet.116.239160.

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