Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009236)
Formula
ES
SVG example
Hydrolysis
Reactant Ingrezza Product (+)-alpha-HTBZ
Reactant Info Product Info
Metabolic Enzyme Esterases (ES) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009235 Ingrezza NBI-136110 Oxidation - Oxidation Ingrezza [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004908 Tetrabenazine Alpha-dihydrotetrabenazine Unclear Tetrabenazine [3]
MR002485 Valbenazine [+]alpha-HTBZ Hydrolysis - Hydrolysis Valbenazine [1], [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004909 Alpha-dihydrotetrabenazine 9-desmethyl-alpha-DHTBZ Unclear Tetrabenazine [3]
References
1 Pharmacologic Characterization of Valbenazine (NBI-98854) and Its Metabolites J Pharmacol Exp Ther. 2017 Jun;361(3):454-461. doi: 10.1124/jpet.116.239160.
2 VMAT2 Inhibitors in Neuropsychiatric Disorders
3 DrugBank(Pharmacology-Metabolism):Tetrabenazine
4 Pharmacokinetic and Pharmacologic Characterization of the Dihydrotetrabenazine Isomers of Deutetrabenazine and Valbenazine. Clin Pharmacol Drug Dev. 2023 Apr;12(4):447-456. doi: 10.1002/cpdd.1205.

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