Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009255)
Formula
CYP1A2 ...
SVG example
Unclear
Reactant Neupro Product N-despropyl-rotigotine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009258 Neupro N-desthienylethyl-rotigotine Unclear - Unclear Neupro [1]
MR009261 Neupro Neupro Metabolite M4 Unclear - Unclear Neupro [1]
MR009262 Neupro Neupro Metabolite M5 Unclear - Unclear Neupro [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010609 N-0923 N-0923 Metabolite M12 Unclear - Unclear N-0923 [3]
MR009594 Rotigotine N-despropyl-rotigotine Unclear - Unclear Rotigotine [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010610 N-0923 Metabolite M12 N-0923 Metabolite M13 Unclear - Unclear N-0923 [3]
MR009596 N-despropyl-rotigotine N-Despropyl rotigotine glucuronide Conjugation - Glucuronidation Rotigotine [1]
MR009595 N-despropyl-rotigotine N-Despropyl rotigotine sulfate Oxidation - Sulfonation Rotigotine [1]
MR009256 N-despropyl-rotigotine Neupro Metabolite M1 Unclear - Unclear Neupro [1]
MR009257 N-despropyl-rotigotine Neupro Metabolite M2 Unclear - Unclear Neupro [1], [4]
References
1 Absorption, disposition, metabolic fate, and elimination of the dopamine agonist rotigotine in man: administration by intravenous infusion or transdermal delivery
2 Identification of the human SULT enzymes involved in the metabolism of rotigotine. J Clin Pharmacol. 2016 Jun;56(6):754-60.
3 Determination of the dopamine D2 agonist N-0923 and its major metabolites in perfused rat livers by HPLC-UV-atmospheric pressure ionization mass spectrometry
4 No influence of the CYP2C19-selective inhibitor omeprazole on the pharmacokinetics of the dopamine receptor agonist rotigotine

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