Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009538)
Formula Reactant Rilpivirine hydrochloride Product Rilpivirine M5
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009536 Rilpivirine hydrochloride Rilpivirine M1 Oxidation - Hydroxylation Rilpivirine hydrochloride [1]
MR009532 Rilpivirine hydrochloride Rilpivirine M2 Oxidation - Hydroxylation Rilpivirine hydrochloride [1]
MR009537 Rilpivirine hydrochloride Rilpivirine M3 Oxidation - Hydroxylation Rilpivirine hydrochloride [1]
MR009534 Rilpivirine hydrochloride Rilpivirine M4 Oxidation - Hydroxylation Rilpivirine hydrochloride [1]
References
1 Human biotransformation of the nonnucleoside reverse transcriptase inhibitor rilpivirine and a cross-species metabolism comparison. Antimicrob Agents Chemother. 2013 Oct;57(10):5067-79.

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