General Information of This Metabolic Reaction (MR) (ID: MR009534)
Formula Reactant Rilpivirine hydrochloride Product Rilpivirine M4
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009536 Rilpivirine hydrochloride Rilpivirine M1 Oxidation - Hydroxylation Rilpivirine hydrochloride [1]
MR009532 Rilpivirine hydrochloride Rilpivirine M2 Oxidation - Hydroxylation Rilpivirine hydrochloride [1]
MR009537 Rilpivirine hydrochloride Rilpivirine M3 Oxidation - Hydroxylation Rilpivirine hydrochloride [1]
MR009538 Rilpivirine hydrochloride Rilpivirine M5 Conjugation - Glucuronidation Rilpivirine hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009535 Rilpivirine M4 Rilpivirine M7 Conjugation - Glucuronidation Rilpivirine hydrochloride [1]
References
1 Human biotransformation of the nonnucleoside reverse transcriptase inhibitor rilpivirine and a cross-species metabolism comparison. Antimicrob Agents Chemother. 2013 Oct;57(10):5067-79.

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