Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009568)
Formula
SVG example
3-hydroxylation
Reactant Ropivacaine hydrochloride Product 3-hydroxyropivacaine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - 3-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009575 Ropivacaine hydrochloride 2-Hydroxymethylropivacaine Oxidation - Methylhydroxylation Ropivacaine hydrochloride [1]
MR009570 Ropivacaine hydrochloride 4-Hydroxyropivacaine Oxidation - 4-hydroxylation Ropivacaine hydrochloride [1]
MR009572 Ropivacaine hydrochloride PPX Oxidation - N-dealkylation Ropivacaine hydrochloride [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009569 3-hydroxyropivacaine 3-OH-PPX Oxidation - N-dealkylation Ropivacaine hydrochloride [4]
References
1 Metabolism and excretion of ropivacaine in humans
2 Regional transport and metabolism of ropivacaine and its CYP3A4 metabolite PPX in human intestine. J Pharm Pharmacol. 2003 Jul;55(7):963-72.
3 Effect of propofol on ropivacaine metabolism in human liver microsomes
4 LABEL:Ropivacaine hydrochloride

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