Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009577)
Formula
SVG example
Hydroxylation
Reactant N-Desmethylrosiglitazone Product N-Desmethyl-para-hydroxy rosiglitazone
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009576 Rosiglitazone N-Desmethylrosiglitazone Oxidation - N-demethylation Rosiglitazone [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009581 N-Desmethylrosiglitazone N-Desmethyl glucuronide rosiglitazone Conjugation - Glucuronidation Rosiglitazone [2]
MR009579 N-Desmethylrosiglitazone N-Desmethyl-ortho-hydroxy rosiglitazone Oxidation - Hydroxylation Rosiglitazone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009583 Para-Hydroxyrosiglitazone N-Desmethyl-para-hydroxy rosiglitazone Oxidation - N-demethylation Rosiglitazone [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009578 N-Desmethyl-para-hydroxy rosiglitazone N-Desmethyl para-O-sulfate rosiglitazone Oxidation - Sulfonation Rosiglitazone [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.

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