Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009576)
Formula
CYP2C8 ...
SVG example
N-demethylation
Reactant Rosiglitazone Product N-Desmethylrosiglitazone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009590 Rosiglitazone N-Despyridinyl rosiglitazone Unclear - Unclear Rosiglitazone [1]
MR009586 Rosiglitazone Ortho-Hydroxyrosiglitazone Oxidation - Hydroxylation Rosiglitazone [1]
MR009582 Rosiglitazone Para-Hydroxyrosiglitazone Oxidation - Hydroxylation Rosiglitazone [1]
MR009591 Rosiglitazone Phenoxyacetic acid derivative of rosiglitazone Oxidation - N-oxidation Rosiglitazone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009581 N-Desmethylrosiglitazone N-Desmethyl glucuronide rosiglitazone Conjugation - Glucuronidation Rosiglitazone [2]
MR009579 N-Desmethylrosiglitazone N-Desmethyl-ortho-hydroxy rosiglitazone Oxidation - Hydroxylation Rosiglitazone [1]
MR009577 N-Desmethylrosiglitazone N-Desmethyl-para-hydroxy rosiglitazone Oxidation - Hydroxylation Rosiglitazone [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.

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