Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009583)
Formula
SVG example
N-demethylation
Reactant Para-Hydroxyrosiglitazone Product N-Desmethyl-para-hydroxy rosiglitazone
Reactant Info Product Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009582 Rosiglitazone Para-Hydroxyrosiglitazone Oxidation - Hydroxylation Rosiglitazone [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009585 Para-Hydroxyrosiglitazone Para-O-Glucuronide rosiglitazone Conjugation - Glucuronidation Rosiglitazone [1]
MR009584 Para-Hydroxyrosiglitazone Para-O-Sulfate rosiglitazone Oxidation - Sulfonation Rosiglitazone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009577 N-Desmethylrosiglitazone N-Desmethyl-para-hydroxy rosiglitazone Oxidation - Hydroxylation Rosiglitazone [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009578 N-Desmethyl-para-hydroxy rosiglitazone N-Desmethyl para-O-sulfate rosiglitazone Oxidation - Sulfonation Rosiglitazone [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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