General Information of This Metabolic Reaction (MR) (ID: MR009840)
Formula Reactant Alpelisib Product Alpelisib Metabolite M1
Reactant Info Product Info
Metabolic Type Multi-steps Reaction - Glucuronidation; oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009841 Alpelisib Alpelisib Metabolite M12 Conjugation - N-Glucuronidation Alpelisib [1]
MR009842 Alpelisib Alpelisib Metabolite M2 Oxidation - Oxidation Alpelisib [1]
MR009835 Alpelisib Alpelisib Metabolite M3 Oxidation - Oxidation Alpelisib [1]
MR009837 Alpelisib Alpelisib Metabolite M4 Unclear - Unclear Alpelisib [1]
MR009843 Alpelisib Alpelisib Metabolite M9 Oxidation - Oxidation Alpelisib [1]
References
1 Absorption, distribution, metabolism, and excretion of [(14)C]BYL719 (alpelisib) in healthy male volunteers. Cancer Chemother Pharmacol. 2015 Oct;76(4):751-60.

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