General Information of This Metabolic Reaction (MR) (ID: MR009843)
Formula Reactant Alpelisib Product Alpelisib Metabolite M9
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009840 Alpelisib Alpelisib Metabolite M1 Multi-steps Reaction - Glucuronidation; oxidation Alpelisib [1]
MR009841 Alpelisib Alpelisib Metabolite M12 Conjugation - N-Glucuronidation Alpelisib [1]
MR009842 Alpelisib Alpelisib Metabolite M2 Oxidation - Oxidation Alpelisib [1]
MR009835 Alpelisib Alpelisib Metabolite M3 Oxidation - Oxidation Alpelisib [1]
MR009837 Alpelisib Alpelisib Metabolite M4 Unclear - Unclear Alpelisib [1]
References
1 Absorption, distribution, metabolism, and excretion of [(14)C]BYL719 (alpelisib) in healthy male volunteers. Cancer Chemother Pharmacol. 2015 Oct;76(4):751-60.

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