Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009860)
Formula Reactant Amitriptyline hydrochloride Product (E)-10-hydroxyamitriptyline
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009858 Amitriptyline hydrochloride (Z)-10-hydroxyamitriptyline Unclear - Unclear Amitriptyline hydrochloride [1], [2]
MR009854 Amitriptyline hydrochloride Nortriptyline Unclear - Unclear Amitriptyline hydrochloride [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009861 (E)-10-hydroxyamitriptyline (E)-10-hydroxynortriptyline Unclear - Unclear Amitriptyline hydrochloride [1], [2]
References
1 CYP2D6 and CYP2C19 genotypes and amitriptyline metabolite ratios in a series of medicolegal autopsies
2 Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype

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