Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009861)
Formula Reactant (E)-10-hydroxyamitriptyline Product (E)-10-hydroxynortriptyline
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009860 Amitriptyline hydrochloride (E)-10-hydroxyamitriptyline Unclear - Unclear Amitriptyline hydrochloride [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009856 Nortriptyline (E)-10-hydroxynortriptyline Unclear - Unclear Amitriptyline hydrochloride [1], [2]
References
1 CYP2D6 and CYP2C19 genotypes and amitriptyline metabolite ratios in a series of medicolegal autopsies
2 Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype

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