Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010376)
Formula
CYP1A1 ...
SVG example
Desmethylation
Reactant Benzoylphenylurea Product MmBPU
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Metabolic Type Oxidation - Desmethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010381 Benzoylphenylurea G373 Unclear - Unclear Benzoylphenylurea [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010377 MmBPU AminoBPU Oxidation - Di-desmethylation Benzoylphenylurea [1], [2]
MR010380 MmBPU G280 Unclear - Unclear Benzoylphenylurea [1], [2]
MR010379 MmBPU G308 Unclear - Unclear Benzoylphenylurea [1], [2]
References
1 In vitro and in vivo clinical pharmacology of dimethyl benzoylphenylurea, a novel oral tubulin-interactive agent
2 Phase I study of continuous weekly dosing of dimethylamino benzoylphenylurea (BPU) in patients with solid tumours

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